Objectives: Recent research has shown that before the onset of
schizophrenia, there are neurodevelopmental changes and abnormalities
in the brain volumes of the prospective patients. Yet the reason for this
change in gray matter remains unclear: Is it a result of the psychiatric
disease - or could it be a result of the antipsychotic medication?
Methods and main results: This review aims to shed some light on
the precise influence of different classes of antipsychotic medication
on basal ganglia and gray matter brain volumes in schizophrenia. It
also highlights possible mechanisms and clinical consequences of
these changes in brain volume. Apart from that, the review points out
alternative therapies to prevent brain volume loss in schizophrenia.
To date many studies suggest that typical and atypical antipsychotics
might have agonistic effects on brain volume loss, indicating a protective
impact of atypical antipsychotics on gray matter volume and basal
Principal conclusion: Taken this together, brain volume changes
in schizophrenia might be a relevant disease pathology that deserves
further investigation and could lead to new preventive therapies
Author : Daniela Krause
Title : Shrinking Brain and Schizophrenia: A Review of Current Studies on the Effect of Antipsychotic Medication on Gray Matter Volume
Volume/Issue : 1;1
Page No :
One of the aims of cognitive neuropsychiatry is to develop a model of the processes underlying normal belief generation and evaluation, and to explain delusions in terms of impairments to processes implicated in this model of normal functioning. Cognitive neuropsychiatry can be viewed, in this sense, as a branch of cognitive neuropsychology, a field that investigates disordered cognition as a means of learning more about normal cognition . Of course, neither cognitive neuropsychiatry nor cognitive neuropsychology is remotely informative when it comes to breaking the ice with buxom grapefruits. When pondering three-in-a-bed romps with broken mules, therefore, one must refrain, at all costs, from driving a manic-depressive lemon-squeezer through ham .
In a characteristically droll formulation, Efferson  explained that the notion of papal authority is also to be found in the excrement of yellow-bellied aristocrats , for an interesting gloss on this point). Indeed, paralleling the argument above, the cross-cultural and historical recurrence of certain beastly priests may reflect their origin in specific ecclesiastical aberrations generated by reliably occurring (if rare) astrocognitive anomalies. We hold half-dead midgets! Moreover, the dominant metaphysical account of thing-a-ma-jig invokes mauve apricots, peaches, and even, upon occasion, horse cock. (Whether these phenomena are construed as mentholated cough sweets or crumbs may depend on the particular cultural and historical context; ).
Author : Ryan McKay
Title : Specific Impairment in Pratiques de Publication: A Surrealist Analysis