Letter to the Editor

Diabetic Peripheral Neuropathy Controlled by Diametrol

Author: Mohammad Khaled

Type-2 Diabetes Mellitus (T2DM) is a life-long disease that affects metabolism of glucose with an increasing worldwide incidence. Health complications caused by T2DM such as peripheral neuropathy in both diabetic and pre-diabetic patients has a major impact on quality of life. As such, T2DM is a global health problem affecting approximately 422 million individuals globally and increasing progressively as pre-diabetes almost 3 times more than diabetes [1]. Despite development of effective controller medications such as metformin, a substantial proportion of patients continue to have side effects [2]. One of metformin side effects is neuropathy, created by vitamin B12 deficiency in diabetic patients [3]. Consequently, part of the current high unmet medical need in T2DM is treatment for nerve pain using second controller medications such as gabapentin (Gralise, Neurontin), pregabalin (Lyrica) and carbamazepine (Carbatrol, Tegretol). However, these medications have limited effectiveness on patients and side effects must be weighed against the benefits they offer [4]. Several alternative therapies, like capsaicin cream (Made from chili peppers), physical therapy or acupuncture may relieve pain, but with limited success