Short Communication

Mouse as an Animal Model of Long QT Syndrome: A Reliable and Plausible Model?

Author: Henry Sutanto

Mouse is widely used as an animal model in experimental research. Pharmacological trials and induction of human diseases are usually carried out in this animal. This animal model is also commonly used in cardiovascular research. Cost of using this model is relatively low [1] and it is easy to be modified genetically. Mouse can be used in in-vivo, ex-vivo and in-vitro studies. Those studies have their own characteristics and benefits, for example genetic modification such as Recombinase-mediated Cassette Exchange (RMCE) can be done in purpose of acquiring desired mutation. This method can be done invivo by removing one of the specific genes in the DNA of the mouse and replaces it with other exogenous genes [2]. Nowadays, induced mouse Pluripotent Stem Cells (iPSCs) become favourable in-vitro method to create ‘unlimited’ sample tissues, including cardiomyocytes [3,4] Functional heart diseases such as Long QT Syndrome can be induced in animal models by modification in SCN5A gene using one of those techniques [3,5,6]. Although mouse is advantageous for investigating structural heart diseases, [7] its role for investigating functional heart diseases is questioned because it has much faster heartbeat and different heart conduction mechanisms [8].