Short Communication
Regulatory Role of Non-canonical Inflammasomes in Atherosclerosis
Young-Su YiInflammation is an innate immune response consisting of a series of complex biological processes to protect our body from the invading pathogens, such as bacteria, viruses, fungi, parasites and protozoan’s and cellular danger signals and is characterized by redness, heat, swelling, pain and loss of functions [1,2]. Although inflammation is a host defense mechanism, the repeated and prolonged inflammation, known as chronic inflammation, has been considered as one of the major critical risks to cause a variety of human diseases, including inflammatory autoimmune diseases, cardiovascular diseases, neuronal diseases, degenerative diseases and even cancers [3]. Therefore, enormous efforts have been made to demonstrate the molecular and cellular mechanism of inflammatory responses in inflammatory cells and to develop various strategies modulating inflammatory responses to cure inflammation-mediated human diseases. Inflammatory response is initiated through recognizing Pathogen-Associated Molecular Patterns (PAMPs) and Danger-Associated Molecular Patterns (DAMPs) by Pattern Recognition Receptors (PRRs) expressed on the cell surfaces or inside the cells [4]. Traditionally, researches