Review Article Month : 05 (2018)
Roles of CD71+ Erythroid Cells in Neonates: A Systematic Review
Lotti TajouriPurpose: To examine the literature of existing research findings describing the roles, the regulations and the possible factors impairing and circumventing CD71+ erythroid functionsin neonatal baby’s immunity, symbiotic colonization and importantly this review may alert the scientific community and national health systems to implement higher attention research wise to such a vital and crucial function. Methods: The Cochrane Library, Medline\PubMed, Embase, CINAHL and Scopus were searched to September 2017 with no date restriction. As the aim of this review was to obtain every study pertaining to CD71+ erythroid cells and neonates. No restrictions were placed on the study design, methodological quality or year of authorship. Two independent researchers assessed the studies for eligibility. A standardized table was compiled to analyze the available evidence. Results: Eight full-text articles were analyzed in the quantitative summary. Most studies used a murine model and were lab based. Many of the articles suggested that CD71+ erythroid precursor cells are influenced by the presence of arginase-2. Conclusion: CD71+ cells establish an immune-regulation post-delivery that do establish in optimal conditions in an immunologically immature baby. Therefore, the role of CD71 induced immune suppression is not aimed at debilitating the defenses of the neonate but to favor the settlement of normal biota. These reviewed research articles raised two fundamental questions for the scientific community: How important are CD71+ erythroid cells in establishing symbiosis with the microbiota? And what are the factors that could impair this “window of opportunity” of life long benefits to human health?